Our core analytical software compares your query antibodies to both the Natural Antibody Reference and the Therapeutic Antibody Reference, indicating known antibodies that fall within a certain sequence identity of your query and allow you to draw conclusions about the nature of the distance from either natural or therapeutic abs.Such insights could be changed into actionables, where one prioritizes a set of candidates because of good statistical properties or selects certain positions for modifications.
Natural Antibody Reference - statistical profiling of what is observably allowed in natural antibodies. Following the logic that large divergence of therapeutic candidates from naturally observable abs might be detrimental. Data here is sourced from naturally-sourced human NGS.
Therapeutic Antibody Reference - statistical profiling of what appears to work in the therapeutic antibody sphere. Following the logic that one should learn from previous engineering endeavors. Data here is sourced from ab therapeutics on the market and patents.