Data and computational products for antibody development

We collect and generate antibody data to inform creation of computational antibody tools. We are licensing out the datasets for internal use at your organization so you can always see the complete picture of publicly available antibody information.We employ this information to create antibody analitical tools to speed up antibody discovery and for scientific decision support.

Patented antibody database

Finding antibodies that are close sequence relatives to previously characterized antibodies with known binding partners is frequently performed to identify antigen-specific sequences.In order to find such shared antibodies, one needs to curate a set of previously characterized antibody sequences, typically from scientific publications and patents. Sequence reporting is heterogeneous and it is cumbersome to find publicly available sets of antibody sequences.

Antibody charts

Analytics

We gather data on naturally sourced and therapeutic antibodies to develop statistical models of both, to act as a reference to a potential antibody therapeutic candidate.

Antibodies from GenBank ®

Antibodies are a class of proteins that evolved to identify noxious molecules in many vertebrates. Binding sites of these molecules are extremely diverse and one of the key questions in antibody engineering is finding a particular sequence, out of many possible ones, targeting a specific molecule's surface.

GenBank

This is often performed by comparing a novel antibody to a previously characterized one with a known binding mode, on assumption that they would share specificity. In order to find such shared antibodies, one needs to curate a set of previously characterized antibody sequences.Sequence reporting is heterogeneous and it is cumbersome to find publicly available sets of antibody sequences. One of the most common outlets for deposition of sequence information is NCBI GenBank. To address the issue we curated databases of antibody sequences from the leading resources such as GenBank, called AbGenBank available at naturalantibody.com/abgenbankWe hope that our databases would facilitate myriad antibody analytics and discovery protocols that need to reference their molecules against those previously characterized.

Conclusion

Identifying previously characterized antibodies is an important step in many antibody analysis pipelines. Finding close-sequence matches from either patents or scientific publications can provide an indication whether a query antibodies (e.g. from Next Generation Sequencing) were previously identified. If the target of the previously characterized antibody is known, it could provide indication of shared specificity to the query antibody. Providing easy-to access search facilities to antibodies from patented sequences (PAD) and those from GenBank (AbGenBank) should benefit antibody analytics pipelines.Both PAD and AbGenBank are available for academic non-commercial use.

Collaborators

We publish our research results with many collaborators across academia and industry.
Our collaborators include:

ACADEMIA

Oxford UniversityCambridge UniversityUtrecht UniversityDanish Technical University

Industrial

AstraZenecaBoehringer IngelheimUCB Pharma